Upregulation of MAPK Negative Feedback Regulators and RET in Mutant ALK Neuroblastoma: Implications for Targeted Treatment.
Identifieur interne : 002669 ( Main/Exploration ); précédent : 002668; suivant : 002670Upregulation of MAPK Negative Feedback Regulators and RET in Mutant ALK Neuroblastoma: Implications for Targeted Treatment.
Auteurs : Irina Lambertz [Belgique] ; Candy Kumps [Belgique] ; Shana Claeys [Belgique] ; Sven Lindner [Allemagne] ; Anneleen Beckers [Belgique] ; Els Janssens [Belgique] ; Daniel R. Carter [Australie] ; Alex Cazes [France] ; Belamy B. Cheung [Australie] ; Marilena De Mariano [Italie] ; An De Bondt [Belgique] ; Sara De Brouwer [Belgique] ; Olivier Delattre [France] ; Jay Gibbons [États-Unis] ; Isabelle Janoueix-Lerosey [France] ; Geneviève Laureys [Belgique] ; Chris Liang [États-Unis] ; Glenn M. Marchall [Australie] ; Michael Porcu [Belgique] ; Junko Takita [Japon] ; David Camacho Trujillo [Belgique] ; Ilse Van Den Wyngaert [Belgique] ; Nadine Van Roy [Belgique] ; Alan Van Goethem [Belgique] ; Tom Van Maerken [Belgique] ; Piotr Zabrocki [Belgique] ; Jan Cools [Belgique] ; Johannes H. Schulte [Allemagne] ; Jorge Vialard [Belgique] ; Frank Speleman [Belgique] ; Katleen De Preter [Belgique]Source :
- Clinical cancer research : an official journal of the American Association for Cancer Research [ 1078-0432 ] ; 2015.
Descripteurs français
- KwdFr :
- Animaux, Humains, Lignée cellulaire tumorale, Mitogen-Activated Protein Kinase Kinases (métabolisme), Neuroblastome (génétique), Neuroblastome (métabolisme), Phosphatase alcaline (génétique), Protéines proto-oncogènes c-ret (métabolisme), Réaction de polymérisation en chaîne, Régulation positive, Résistance aux médicaments antinéoplasiques (génétique), Rétrocontrôle physiologique, Souris, Souris transgéniques, Séquençage par oligonucléotides en batterie, Technique de Western, Thérapie moléculaire ciblée (), Transcriptome.
- MESH :
- génétique : Neuroblastome, Phosphatase alcaline, Résistance aux médicaments antinéoplasiques.
- métabolisme : Mitogen-Activated Protein Kinase Kinases, Neuroblastome, Protéines proto-oncogènes c-ret.
- Animaux, Humains, Lignée cellulaire tumorale, Réaction de polymérisation en chaîne, Régulation positive, Rétrocontrôle physiologique, Souris, Souris transgéniques, Séquençage par oligonucléotides en batterie, Technique de Western, Thérapie moléculaire ciblée, Transcriptome.
English descriptors
- KwdEn :
- Alkaline Phosphatase (genetics), Animals, Blotting, Western, Cell Line, Tumor, Drug Resistance, Neoplasm (genetics), Feedback, Physiological, Humans, Mice, Mice, Transgenic, Mitogen-Activated Protein Kinase Kinases (metabolism), Molecular Targeted Therapy (methods), Neuroblastoma (genetics), Neuroblastoma (metabolism), Oligonucleotide Array Sequence Analysis, Polymerase Chain Reaction, Proto-Oncogene Proteins c-ret (metabolism), Transcriptome, Up-Regulation.
- MESH :
- chemical , genetics : Alkaline Phosphatase.
- genetics : Drug Resistance, Neoplasm, Neuroblastoma.
- chemical , metabolism : Mitogen-Activated Protein Kinase Kinases, Neuroblastoma, Proto-Oncogene Proteins c-ret.
- methods : Molecular Targeted Therapy.
- Animals, Blotting, Western, Cell Line, Tumor, Feedback, Physiological, Humans, Mice, Mice, Transgenic, Oligonucleotide Array Sequence Analysis, Polymerase Chain Reaction, Transcriptome, Up-Regulation.
Abstract
Activating ALK mutations are present in almost 10% of primary neuroblastomas and mark patients for treatment with small-molecule ALK inhibitors in clinical trials. However, recent studies have shown that multiple mechanisms drive resistance to these molecular therapies. We anticipated that detailed mapping of the oncogenic ALK-driven signaling in neuroblastoma can aid to identify potential fragile nodes as additional targets for combination therapies.
DOI: 10.1158/1078-0432.CCR-14-2024
PubMed: 25805801
Affiliations:
- Allemagne, Australie, Belgique, France, Italie, Japon, États-Unis
- Floride, Nouvelle-Galles du Sud, Région de Kantō, Île-de-France
- Paris, Sydney, Tokyo
- Université de Tokyo
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Le document en format XML
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Marchall</name><affiliation wicri:level="3"><nlm:affiliation>Kids Cancer Center, Sydneys Children's Hospital, Children's Cancer Institute, Lowy Cancer Centre, University of New South Wales, Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Kids Cancer Center, Sydneys Children's Hospital, Children's Cancer Institute, Lowy Cancer Centre, University of New South Wales, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Porcu, Michael" sort="Porcu, Michael" uniqKey="Porcu M" first="Michael" last="Porcu">Michael Porcu</name><affiliation wicri:level="1"><nlm:affiliation>Center for Human Genetics, K.U. Leuven-VIB, Leuven, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Center for Human Genetics, K.U. Leuven-VIB, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Takita, Junko" sort="Takita, Junko" uniqKey="Takita J" first="Junko" last="Takita">Junko Takita</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pediatrics, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pediatrics, Graduate School of Medicine, the University of Tokyo, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region><settlement type="city">Tokyo</settlement></placeName><orgName type="university">Université de Tokyo</orgName></affiliation></author><author><name sortKey="Trujillo, David Camacho" sort="Trujillo, David Camacho" uniqKey="Trujillo D" first="David Camacho" last="Trujillo">David Camacho Trujillo</name><affiliation wicri:level="1"><nlm:affiliation>Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Center for Medical Genetics, Ghent University Hospital, Ghent</wicri:regionArea><wicri:noRegion>Ghent</wicri:noRegion></affiliation></author><author><name sortKey="Van Den Wyngaert, Ilse" sort="Van Den Wyngaert, Ilse" uniqKey="Van Den Wyngaert I" first="Ilse" last="Van Den Wyngaert">Ilse Van Den Wyngaert</name><affiliation wicri:level="1"><nlm:affiliation>Oncology Discovery Research and Early Development, Johnson & Johnson, Beerse, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Oncology Discovery Research and Early Development, Johnson & Johnson, Beerse</wicri:regionArea><wicri:noRegion>Beerse</wicri:noRegion></affiliation></author><author><name sortKey="Van Roy, Nadine" sort="Van Roy, Nadine" uniqKey="Van Roy N" first="Nadine" last="Van Roy">Nadine Van Roy</name><affiliation wicri:level="1"><nlm:affiliation>Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Center for Medical Genetics, Ghent University Hospital, Ghent</wicri:regionArea><wicri:noRegion>Ghent</wicri:noRegion></affiliation></author><author><name sortKey="Van Goethem, Alan" sort="Van Goethem, Alan" uniqKey="Van Goethem A" first="Alan" last="Van Goethem">Alan Van Goethem</name><affiliation wicri:level="1"><nlm:affiliation>Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Center for Medical Genetics, Ghent University Hospital, Ghent</wicri:regionArea><wicri:noRegion>Ghent</wicri:noRegion></affiliation></author><author><name sortKey="Van Maerken, Tom" sort="Van Maerken, Tom" uniqKey="Van Maerken T" first="Tom" last="Van Maerken">Tom Van Maerken</name><affiliation wicri:level="1"><nlm:affiliation>Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Center for Medical Genetics, Ghent University Hospital, Ghent</wicri:regionArea><wicri:noRegion>Ghent</wicri:noRegion></affiliation></author><author><name sortKey="Zabrocki, Piotr" sort="Zabrocki, Piotr" uniqKey="Zabrocki P" first="Piotr" last="Zabrocki">Piotr Zabrocki</name><affiliation wicri:level="1"><nlm:affiliation>Center for Human Genetics, K.U. Leuven-VIB, Leuven, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Center for Human Genetics, K.U. Leuven-VIB, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Cools, Jan" sort="Cools, Jan" uniqKey="Cools J" first="Jan" last="Cools">Jan Cools</name><affiliation wicri:level="1"><nlm:affiliation>Center for Human Genetics, K.U. Leuven-VIB, Leuven, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Center for Human Genetics, K.U. Leuven-VIB, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Schulte, Johannes H" sort="Schulte, Johannes H" uniqKey="Schulte J" first="Johannes H" last="Schulte">Johannes H. Schulte</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatric Oncology and Haematology, University Children's Hospital Essen, Germany. German Cancer Consortium (DKTK), Germany. Translational Neuro-Oncology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, Essen, Germany. German Cancer Research Center (DKFZ), Heidelberg, Germany. Centre for Medical Biotechnology, University Duisburg-Essen, Essen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pediatric Oncology and Haematology, University Children's Hospital Essen, Germany. German Cancer Consortium (DKTK), Germany. Translational Neuro-Oncology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, Essen, Germany. German Cancer Research Center (DKFZ), Heidelberg, Germany. Centre for Medical Biotechnology, University Duisburg-Essen, Essen</wicri:regionArea><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion></affiliation></author><author><name sortKey="Vialard, Jorge" sort="Vialard, Jorge" uniqKey="Vialard J" first="Jorge" last="Vialard">Jorge Vialard</name><affiliation wicri:level="1"><nlm:affiliation>Oncology Discovery Biology, Janssen Research & Development, a division of Janssen Pharmaceutica NV, Beerse, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Oncology Discovery Biology, Janssen Research & Development, a division of Janssen Pharmaceutica NV, Beerse</wicri:regionArea><wicri:noRegion>Beerse</wicri:noRegion></affiliation></author><author><name sortKey="Speleman, Frank" sort="Speleman, Frank" uniqKey="Speleman F" first="Frank" last="Speleman">Frank Speleman</name><affiliation wicri:level="1"><nlm:affiliation>Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium. franki.speleman@ugent.be.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Center for Medical Genetics, Ghent University Hospital, Ghent</wicri:regionArea><wicri:noRegion>Ghent</wicri:noRegion></affiliation></author><author><name sortKey="De Preter, Katleen" sort="De Preter, Katleen" uniqKey="De Preter K" first="Katleen" last="De Preter">Katleen De Preter</name><affiliation wicri:level="1"><nlm:affiliation>Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Center for Medical Genetics, Ghent University Hospital, Ghent</wicri:regionArea><wicri:noRegion>Ghent</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25805801</idno><idno type="pmid">25805801</idno><idno type="doi">10.1158/1078-0432.CCR-14-2024</idno><idno 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Targeted Treatment.</title><author><name sortKey="Lambertz, Irina" sort="Lambertz, Irina" uniqKey="Lambertz I" first="Irina" last="Lambertz">Irina Lambertz</name><affiliation wicri:level="1"><nlm:affiliation>Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Center for Medical Genetics, Ghent University Hospital, Ghent</wicri:regionArea><wicri:noRegion>Ghent</wicri:noRegion></affiliation></author><author><name sortKey="Kumps, Candy" sort="Kumps, Candy" uniqKey="Kumps C" first="Candy" last="Kumps">Candy Kumps</name><affiliation wicri:level="1"><nlm:affiliation>Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Center for Medical Genetics, Ghent University Hospital, Ghent</wicri:regionArea><wicri:noRegion>Ghent</wicri:noRegion></affiliation></author><author><name sortKey="Claeys, Shana" sort="Claeys, Shana" uniqKey="Claeys S" first="Shana" last="Claeys">Shana Claeys</name><affiliation wicri:level="1"><nlm:affiliation>Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Center for Medical Genetics, Ghent University Hospital, Ghent</wicri:regionArea><wicri:noRegion>Ghent</wicri:noRegion></affiliation></author><author><name sortKey="Lindner, Sven" sort="Lindner, Sven" uniqKey="Lindner S" first="Sven" last="Lindner">Sven Lindner</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatric Oncology and Haematology, University Children's Hospital Essen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pediatric Oncology and Haematology, University Children's Hospital Essen</wicri:regionArea><wicri:noRegion>University Children's Hospital Essen</wicri:noRegion><wicri:noRegion>University Children's Hospital Essen</wicri:noRegion><wicri:noRegion>University Children's Hospital Essen</wicri:noRegion></affiliation></author><author><name sortKey="Beckers, Anneleen" sort="Beckers, Anneleen" uniqKey="Beckers A" first="Anneleen" last="Beckers">Anneleen Beckers</name><affiliation wicri:level="1"><nlm:affiliation>Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Center for Medical Genetics, Ghent University Hospital, Ghent</wicri:regionArea><wicri:noRegion>Ghent</wicri:noRegion></affiliation></author><author><name sortKey="Janssens, Els" sort="Janssens, Els" uniqKey="Janssens E" first="Els" last="Janssens">Els Janssens</name><affiliation wicri:level="1"><nlm:affiliation>Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Center for Medical Genetics, Ghent University Hospital, Ghent</wicri:regionArea><wicri:noRegion>Ghent</wicri:noRegion></affiliation></author><author><name sortKey="Carter, Daniel R" sort="Carter, Daniel R" uniqKey="Carter D" first="Daniel R" last="Carter">Daniel R. Carter</name><affiliation wicri:level="3"><nlm:affiliation>Kids Cancer Center, Sydneys Children's Hospital, Children's Cancer Institute, Lowy Cancer Centre, University of New South Wales, Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Kids Cancer Center, Sydneys Children's Hospital, Children's Cancer Institute, Lowy Cancer Centre, University of New South Wales, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Cazes, Alex" sort="Cazes, Alex" uniqKey="Cazes A" first="Alex" last="Cazes">Alex Cazes</name><affiliation wicri:level="3"><nlm:affiliation>Unité Inserm U830, Centre de Recherche, Institut Curie, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Unité Inserm U830, Centre de Recherche, Institut Curie, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Cheung, Belamy B" sort="Cheung, Belamy B" uniqKey="Cheung B" first="Belamy B" last="Cheung">Belamy B. Cheung</name><affiliation wicri:level="3"><nlm:affiliation>Kids Cancer Center, Sydneys Children's Hospital, Children's Cancer Institute, Lowy Cancer Centre, University of New South Wales, Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Kids Cancer Center, Sydneys Children's Hospital, Children's Cancer Institute, Lowy Cancer Centre, University of New South Wales, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="De Mariano, Marilena" sort="De Mariano, Marilena" uniqKey="De Mariano M" first="Marilena" last="De Mariano">Marilena De Mariano</name><affiliation wicri:level="1"><nlm:affiliation>Biotherapy Unit, IRCCS AOU San Martino-IST, Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Biotherapy Unit, IRCCS AOU San Martino-IST, Istituto Nazionale per la Ricerca sul Cancro, Genoa</wicri:regionArea><wicri:noRegion>Genoa</wicri:noRegion></affiliation></author><author><name sortKey="De Bondt, An" sort="De Bondt, An" uniqKey="De Bondt A" first="An" last="De Bondt">An De Bondt</name><affiliation wicri:level="1"><nlm:affiliation>Oncology Discovery Research and Early Development, Johnson & Johnson, Beerse, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Oncology Discovery Research and Early Development, Johnson & Johnson, Beerse</wicri:regionArea><wicri:noRegion>Beerse</wicri:noRegion></affiliation></author><author><name sortKey="De Brouwer, Sara" sort="De Brouwer, Sara" uniqKey="De Brouwer S" first="Sara" last="De Brouwer">Sara De Brouwer</name><affiliation wicri:level="1"><nlm:affiliation>Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Center for Medical Genetics, Ghent University Hospital, Ghent</wicri:regionArea><wicri:noRegion>Ghent</wicri:noRegion></affiliation></author><author><name sortKey="Delattre, Olivier" sort="Delattre, Olivier" uniqKey="Delattre O" first="Olivier" last="Delattre">Olivier Delattre</name><affiliation wicri:level="3"><nlm:affiliation>Unité Inserm U830, Centre de Recherche, Institut Curie, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Unité Inserm U830, Centre de Recherche, Institut Curie, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Gibbons, Jay" sort="Gibbons, Jay" uniqKey="Gibbons J" first="Jay" last="Gibbons">Jay Gibbons</name><affiliation wicri:level="2"><nlm:affiliation>VP Oncology, Xcovery LLC, West Palm Beach, Florida.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>VP Oncology, Xcovery LLC, West Palm Beach</wicri:cityArea></affiliation></author><author><name sortKey="Janoueix Lerosey, Isabelle" sort="Janoueix Lerosey, Isabelle" uniqKey="Janoueix Lerosey I" first="Isabelle" last="Janoueix-Lerosey">Isabelle Janoueix-Lerosey</name><affiliation wicri:level="3"><nlm:affiliation>Unité Inserm U830, Centre de Recherche, Institut Curie, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Unité Inserm U830, Centre de Recherche, Institut Curie, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Laureys, Genevieve" sort="Laureys, Genevieve" uniqKey="Laureys G" first="Geneviève" last="Laureys">Geneviève Laureys</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatric Oncology and Haematology, Ghent University Hospital, Ghent, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Pediatric Oncology and Haematology, Ghent University Hospital, Ghent</wicri:regionArea><wicri:noRegion>Ghent</wicri:noRegion></affiliation></author><author><name sortKey="Liang, Chris" sort="Liang, Chris" uniqKey="Liang C" first="Chris" last="Liang">Chris Liang</name><affiliation wicri:level="2"><nlm:affiliation>VP Oncology, Xcovery LLC, West Palm Beach, Florida.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>VP Oncology, Xcovery LLC, West Palm Beach</wicri:cityArea></affiliation></author><author><name sortKey="Marchall, Glenn M" sort="Marchall, Glenn M" uniqKey="Marchall G" first="Glenn M" last="Marchall">Glenn M. Marchall</name><affiliation wicri:level="3"><nlm:affiliation>Kids Cancer Center, Sydneys Children's Hospital, Children's Cancer Institute, Lowy Cancer Centre, University of New South Wales, Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Kids Cancer Center, Sydneys Children's Hospital, Children's Cancer Institute, Lowy Cancer Centre, University of New South Wales, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Porcu, Michael" sort="Porcu, Michael" uniqKey="Porcu M" first="Michael" last="Porcu">Michael Porcu</name><affiliation wicri:level="1"><nlm:affiliation>Center for Human Genetics, K.U. Leuven-VIB, Leuven, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Center for Human Genetics, K.U. Leuven-VIB, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Takita, Junko" sort="Takita, Junko" uniqKey="Takita J" first="Junko" last="Takita">Junko Takita</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pediatrics, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pediatrics, Graduate School of Medicine, the University of Tokyo, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region><settlement type="city">Tokyo</settlement></placeName><orgName type="university">Université de Tokyo</orgName></affiliation></author><author><name sortKey="Trujillo, David Camacho" sort="Trujillo, David Camacho" uniqKey="Trujillo D" first="David Camacho" last="Trujillo">David Camacho Trujillo</name><affiliation wicri:level="1"><nlm:affiliation>Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Center for Medical Genetics, Ghent University Hospital, Ghent</wicri:regionArea><wicri:noRegion>Ghent</wicri:noRegion></affiliation></author><author><name sortKey="Van Den Wyngaert, Ilse" sort="Van Den Wyngaert, Ilse" uniqKey="Van Den Wyngaert I" first="Ilse" last="Van Den Wyngaert">Ilse Van Den Wyngaert</name><affiliation wicri:level="1"><nlm:affiliation>Oncology Discovery Research and Early Development, Johnson & Johnson, Beerse, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Oncology Discovery Research and Early Development, Johnson & Johnson, Beerse</wicri:regionArea><wicri:noRegion>Beerse</wicri:noRegion></affiliation></author><author><name sortKey="Van Roy, Nadine" sort="Van Roy, Nadine" uniqKey="Van Roy N" first="Nadine" last="Van Roy">Nadine Van Roy</name><affiliation wicri:level="1"><nlm:affiliation>Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Center for Medical Genetics, Ghent University Hospital, Ghent</wicri:regionArea><wicri:noRegion>Ghent</wicri:noRegion></affiliation></author><author><name sortKey="Van Goethem, Alan" sort="Van Goethem, Alan" uniqKey="Van Goethem A" first="Alan" last="Van Goethem">Alan Van Goethem</name><affiliation wicri:level="1"><nlm:affiliation>Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Center for Medical Genetics, Ghent University Hospital, Ghent</wicri:regionArea><wicri:noRegion>Ghent</wicri:noRegion></affiliation></author><author><name sortKey="Van Maerken, Tom" sort="Van Maerken, Tom" uniqKey="Van Maerken T" first="Tom" last="Van Maerken">Tom Van Maerken</name><affiliation wicri:level="1"><nlm:affiliation>Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Center for Medical Genetics, Ghent University Hospital, Ghent</wicri:regionArea><wicri:noRegion>Ghent</wicri:noRegion></affiliation></author><author><name sortKey="Zabrocki, Piotr" sort="Zabrocki, Piotr" uniqKey="Zabrocki P" first="Piotr" last="Zabrocki">Piotr Zabrocki</name><affiliation wicri:level="1"><nlm:affiliation>Center for Human Genetics, K.U. Leuven-VIB, Leuven, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Center for Human Genetics, K.U. Leuven-VIB, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Cools, Jan" sort="Cools, Jan" uniqKey="Cools J" first="Jan" last="Cools">Jan Cools</name><affiliation wicri:level="1"><nlm:affiliation>Center for Human Genetics, K.U. Leuven-VIB, Leuven, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Center for Human Genetics, K.U. Leuven-VIB, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Schulte, Johannes H" sort="Schulte, Johannes H" uniqKey="Schulte J" first="Johannes H" last="Schulte">Johannes H. Schulte</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatric Oncology and Haematology, University Children's Hospital Essen, Germany. German Cancer Consortium (DKTK), Germany. Translational Neuro-Oncology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, Essen, Germany. German Cancer Research Center (DKFZ), Heidelberg, Germany. Centre for Medical Biotechnology, University Duisburg-Essen, Essen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pediatric Oncology and Haematology, University Children's Hospital Essen, Germany. German Cancer Consortium (DKTK), Germany. Translational Neuro-Oncology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, Essen, Germany. German Cancer Research Center (DKFZ), Heidelberg, Germany. Centre for Medical Biotechnology, University Duisburg-Essen, Essen</wicri:regionArea><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion></affiliation></author><author><name sortKey="Vialard, Jorge" sort="Vialard, Jorge" uniqKey="Vialard J" first="Jorge" last="Vialard">Jorge Vialard</name><affiliation wicri:level="1"><nlm:affiliation>Oncology Discovery Biology, Janssen Research & Development, a division of Janssen Pharmaceutica NV, Beerse, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Oncology Discovery Biology, Janssen Research & Development, a division of Janssen Pharmaceutica NV, Beerse</wicri:regionArea><wicri:noRegion>Beerse</wicri:noRegion></affiliation></author><author><name sortKey="Speleman, Frank" sort="Speleman, Frank" uniqKey="Speleman F" first="Frank" last="Speleman">Frank Speleman</name><affiliation wicri:level="1"><nlm:affiliation>Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium. franki.speleman@ugent.be.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Center for Medical Genetics, Ghent University Hospital, Ghent</wicri:regionArea><wicri:noRegion>Ghent</wicri:noRegion></affiliation></author><author><name sortKey="De Preter, Katleen" sort="De Preter, Katleen" uniqKey="De Preter K" first="Katleen" last="De Preter">Katleen De Preter</name><affiliation wicri:level="1"><nlm:affiliation>Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Center for Medical Genetics, Ghent University Hospital, Ghent</wicri:regionArea><wicri:noRegion>Ghent</wicri:noRegion></affiliation></author></analytic><series><title level="j">Clinical cancer research : an official journal of the American Association for Cancer Research</title><idno type="ISSN">1078-0432</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alkaline Phosphatase (genetics)</term><term>Animals</term><term>Blotting, Western</term><term>Cell Line, Tumor</term><term>Drug Resistance, Neoplasm (genetics)</term><term>Feedback, Physiological</term><term>Humans</term><term>Mice</term><term>Mice, Transgenic</term><term>Mitogen-Activated Protein Kinase Kinases (metabolism)</term><term>Molecular Targeted Therapy (methods)</term><term>Neuroblastoma (genetics)</term><term>Neuroblastoma (metabolism)</term><term>Oligonucleotide Array Sequence Analysis</term><term>Polymerase Chain Reaction</term><term>Proto-Oncogene Proteins c-ret (metabolism)</term><term>Transcriptome</term><term>Up-Regulation</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Humains</term><term>Lignée cellulaire tumorale</term><term>Mitogen-Activated Protein Kinase Kinases (métabolisme)</term><term>Neuroblastome (génétique)</term><term>Neuroblastome (métabolisme)</term><term>Phosphatase alcaline (génétique)</term><term>Protéines proto-oncogènes c-ret (métabolisme)</term><term>Réaction de polymérisation en chaîne</term><term>Régulation positive</term><term>Résistance aux médicaments antinéoplasiques (génétique)</term><term>Rétrocontrôle physiologique</term><term>Souris</term><term>Souris transgéniques</term><term>Séquençage par oligonucléotides en batterie</term><term>Technique de Western</term><term>Thérapie moléculaire ciblée ()</term><term>Transcriptome</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Alkaline Phosphatase</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Drug Resistance, Neoplasm</term><term>Neuroblastoma</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Neuroblastome</term><term>Phosphatase alcaline</term><term>Résistance aux médicaments antinéoplasiques</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Mitogen-Activated Protein Kinase Kinases</term><term>Neuroblastoma</term><term>Proto-Oncogene Proteins c-ret</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Molecular Targeted Therapy</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Mitogen-Activated Protein Kinase Kinases</term><term>Neuroblastome</term><term>Protéines proto-oncogènes c-ret</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Blotting, Western</term><term>Cell Line, Tumor</term><term>Feedback, Physiological</term><term>Humans</term><term>Mice</term><term>Mice, Transgenic</term><term>Oligonucleotide Array Sequence Analysis</term><term>Polymerase Chain Reaction</term><term>Transcriptome</term><term>Up-Regulation</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Humains</term><term>Lignée cellulaire tumorale</term><term>Réaction de polymérisation en chaîne</term><term>Régulation positive</term><term>Rétrocontrôle physiologique</term><term>Souris</term><term>Souris transgéniques</term><term>Séquençage par oligonucléotides en batterie</term><term>Technique de Western</term><term>Thérapie moléculaire ciblée</term><term>Transcriptome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Activating ALK mutations are present in almost 10% of primary neuroblastomas and mark patients for treatment with small-molecule ALK inhibitors in clinical trials. However, recent studies have shown that multiple mechanisms drive resistance to these molecular therapies. We anticipated that detailed mapping of the oncogenic ALK-driven signaling in neuroblastoma can aid to identify potential fragile nodes as additional targets for combination therapies.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Belgique</li><li>France</li><li>Italie</li><li>Japon</li><li>États-Unis</li></country><region><li>Floride</li><li>Nouvelle-Galles du Sud</li><li>Région de Kantō</li><li>Île-de-France</li></region><settlement><li>Paris</li><li>Sydney</li><li>Tokyo</li></settlement><orgName><li>Université de Tokyo</li></orgName></list><tree><country name="Belgique"><noRegion><name sortKey="Lambertz, Irina" sort="Lambertz, Irina" uniqKey="Lambertz I" first="Irina" last="Lambertz">Irina Lambertz</name></noRegion><name sortKey="Beckers, Anneleen" sort="Beckers, Anneleen" uniqKey="Beckers A" first="Anneleen" last="Beckers">Anneleen Beckers</name><name sortKey="Claeys, Shana" sort="Claeys, Shana" uniqKey="Claeys S" first="Shana" last="Claeys">Shana Claeys</name><name sortKey="Cools, Jan" sort="Cools, Jan" uniqKey="Cools J" first="Jan" last="Cools">Jan Cools</name><name sortKey="De Bondt, An" sort="De Bondt, An" uniqKey="De Bondt A" first="An" last="De Bondt">An De Bondt</name><name sortKey="De Brouwer, Sara" sort="De Brouwer, Sara" uniqKey="De Brouwer S" first="Sara" last="De Brouwer">Sara De Brouwer</name><name sortKey="De Preter, Katleen" sort="De Preter, Katleen" uniqKey="De Preter K" first="Katleen" last="De Preter">Katleen De Preter</name><name sortKey="Janssens, Els" sort="Janssens, Els" uniqKey="Janssens E" first="Els" last="Janssens">Els Janssens</name><name sortKey="Kumps, Candy" sort="Kumps, Candy" uniqKey="Kumps C" first="Candy" last="Kumps">Candy Kumps</name><name sortKey="Laureys, Genevieve" sort="Laureys, Genevieve" uniqKey="Laureys G" first="Geneviève" last="Laureys">Geneviève Laureys</name><name sortKey="Porcu, Michael" sort="Porcu, Michael" uniqKey="Porcu M" first="Michael" last="Porcu">Michael Porcu</name><name sortKey="Speleman, Frank" sort="Speleman, Frank" uniqKey="Speleman F" first="Frank" last="Speleman">Frank Speleman</name><name sortKey="Trujillo, David Camacho" sort="Trujillo, David Camacho" uniqKey="Trujillo D" first="David Camacho" last="Trujillo">David Camacho Trujillo</name><name sortKey="Van Den Wyngaert, Ilse" sort="Van Den Wyngaert, Ilse" uniqKey="Van Den Wyngaert I" first="Ilse" last="Van Den Wyngaert">Ilse Van Den Wyngaert</name><name sortKey="Van Goethem, Alan" sort="Van Goethem, Alan" uniqKey="Van Goethem A" first="Alan" last="Van Goethem">Alan Van Goethem</name><name sortKey="Van Maerken, Tom" sort="Van Maerken, Tom" uniqKey="Van Maerken T" first="Tom" last="Van Maerken">Tom Van Maerken</name><name sortKey="Van Roy, Nadine" sort="Van Roy, Nadine" uniqKey="Van Roy N" first="Nadine" last="Van Roy">Nadine Van Roy</name><name sortKey="Vialard, Jorge" sort="Vialard, Jorge" uniqKey="Vialard J" first="Jorge" last="Vialard">Jorge Vialard</name><name sortKey="Zabrocki, Piotr" sort="Zabrocki, Piotr" uniqKey="Zabrocki P" first="Piotr" last="Zabrocki">Piotr Zabrocki</name></country><country name="Allemagne"><noRegion><name sortKey="Lindner, Sven" sort="Lindner, Sven" uniqKey="Lindner S" first="Sven" last="Lindner">Sven Lindner</name></noRegion><name sortKey="Schulte, Johannes H" sort="Schulte, Johannes H" uniqKey="Schulte J" first="Johannes H" last="Schulte">Johannes H. Schulte</name></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Carter, Daniel R" sort="Carter, Daniel R" uniqKey="Carter D" first="Daniel R" last="Carter">Daniel R. Carter</name></region><name sortKey="Cheung, Belamy B" sort="Cheung, Belamy B" uniqKey="Cheung B" first="Belamy B" last="Cheung">Belamy B. Cheung</name><name sortKey="Marchall, Glenn M" sort="Marchall, Glenn M" uniqKey="Marchall G" first="Glenn M" last="Marchall">Glenn M. Marchall</name></country><country name="France"><region name="Île-de-France"><name sortKey="Cazes, Alex" sort="Cazes, Alex" uniqKey="Cazes A" first="Alex" last="Cazes">Alex Cazes</name></region><name sortKey="Delattre, Olivier" sort="Delattre, Olivier" uniqKey="Delattre O" first="Olivier" last="Delattre">Olivier Delattre</name><name sortKey="Janoueix Lerosey, Isabelle" sort="Janoueix Lerosey, Isabelle" uniqKey="Janoueix Lerosey I" first="Isabelle" last="Janoueix-Lerosey">Isabelle Janoueix-Lerosey</name></country><country name="Italie"><noRegion><name sortKey="De Mariano, Marilena" sort="De Mariano, Marilena" uniqKey="De Mariano M" first="Marilena" last="De Mariano">Marilena De Mariano</name></noRegion></country><country name="États-Unis"><region name="Floride"><name sortKey="Gibbons, Jay" sort="Gibbons, Jay" uniqKey="Gibbons J" first="Jay" last="Gibbons">Jay Gibbons</name></region><name sortKey="Liang, Chris" sort="Liang, Chris" uniqKey="Liang C" first="Chris" last="Liang">Chris Liang</name></country><country name="Japon"><region name="Région de Kantō"><name sortKey="Takita, Junko" sort="Takita, Junko" uniqKey="Takita J" first="Junko" last="Takita">Junko Takita</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= Upregulation of MAPK Negative Feedback Regulators and RET in Mutant ALK Neuroblastoma: Implications for Targeted Treatment.
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Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:25805801" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |